1,3,5-TRIHYDROXYBENZENE

PRODUCT IDENTIFICATION
CAS NO. 108-73-6

1,3,5-TRIHYDROXY BENZENE

EINECS NO. 203-611-2
FORMULA C6H3(OH)3
MOL WT. 126.11

H.S. CODE

2907.29

TOXICITY

 Oral rat LD50: 4000 mg/kg
SYNONYMS

Phloroglucinol; s-Trihydroxybenzene; Benzene-s-triol;

1,3,5-Benzenetriol; 1,3,5-trihydroxybenzene; 1,3,5-THB; Phloroglucin; Phloroglucine; sym-Trihydroxybenzene; 1,3,5-Trihydroxycyclohexatriene; 3,5-Dihydroxyphenol; 5-Hydroxyresorcinol; 5-Oxyresorcinolphloroglucin; Benzene-1,3,5-triol; Dilospan S; Floroglucin; Floroglucinol; 5-Oxyresorcinol; 1,3,5-Triol;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to off-white powder
MELTING POINT 218 - 221C by rapid heating, 200-209 C by slow heating
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Soluble (1.06E+04 mg/l at 20 C)

SOLVENT SOLUBILITY

 soluble in alcohol and ether
pH  
VAPOR DENSITY

4.3

pKa 8.45 (Dissociation Constant at 20 C)
log Pow 0.16 (Octanol-water)
VAPOR PRESSURE 1.60E-04 (mmHg at 25 C)
HENRY'S LAW 6.07E-15 (atm-m3/mole at 25 C)
OH RATE 2.00E-10  at 25 C (Atmospheric)

AUTOIGNITION

 

NFPA RATINGS

 Health: 1 Flammability: 1 Reactivity: 1

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & EXTERNAL LINKS
There are three isomeric compounds of trihydroxybenzene molecule structure, which all have traditional names respectively. Their names are related with the equivalent dihydroxybenzene compounds. The names of the three compounds indicate which of the hydrogens on the benzene ring portion of the molecule have been replaced by hydroxyl groups. The isomer of 1,2,3-trihydroxybenzene is called pyrogallic acid (or pyrogallol).  This compound is a poisonous acid, derived from gallic acid, and used  in the manufacturing colorants such as azo dyes and photographic developers and externally as an antimicrobial to treat certain skin diseases. Phloroglucin (or called phloroglucinol) is 1,3,5-trihydroxybenzene which presents as the genin of many glycosides, particulrally in the bark of apple and other trees. It is used in as a reagent for pentoses, pentosans, glycuronates, hydrochloric acid in gastric juice. It is an excellent bone decalcifying agent and a floral preservative. It is used in the manufacture of pharmaceuticals. The 1,2,4- isomer is hydroxyquinol (or called hydroxyhydroquinone). Trihydroxybenzenes have three hydroxyl groups in one benzene ring. They can derive numerous esters and salts. They are used as chemical intermediate to synthesis target molecules of pharmaceuticals, pesticides, stabilizer, antioxidant, colorants, perfumes, photoinitiators, and other organic compounds.

Members of phloroglucinol molecules

Product

CAS RN
2,4,6-Trihydroxybenzoic acid 83-30-7
2-Methylphloroglucinol 88-03-9
Phloroglucinol 108-73-6
1-(2,4,6-Trihydroxyphenyl)ethanone 480-66-0
2,4,6-Trihydroxybenzaldehyde 487-70-7
Phloroglucinol dimethyl ether 500-99-2
1,3,5-Trimethoxybenzene 621-23-8
2,4-Diacetylphloroglucilmethane 726-28-3
2-Bromo-1,3,5-trimethoxybenzene 1131-40-4
2,4-Diacetylphloroglucinol 2161-86-6
Flopropione 2295-58-1
1,3,5-Benzenetriol triacetate 2999-40-8
2,4,6-Tribromo-1,3,5-benzenetriol 3354-82-3
2,4-Dimethylphloroglucinol 4463-02-9
Trimethylphloroglucinol 4463-03-0
1,3,5-Benzenetriol dihydrate 6099-90-7
Polyphloroglucinol phosphate 9014-68-0
2-Nitrophloroglucinol 16600-92-3
1,3,5-Trimethoxy-2-(phenylmethyl)benzene 22807-99-4
2,4-Dihydroxy-6-(3,4-dihydroxybenzoyloxy)benzoic acid 30048-34-1
Trinitrophloroglucinol lead salt 51325-28-1
Trichlorophloroglucinol 56961-23-0
2-Chloro-1,3,5-trimethoxybenzene 67827-56-9
2-Ethyl-1,3,5-trimethoxybenzene 67827-55-8
2-(3-(3-Hydroxy-4-methoxyphenyl)propyl)-1,3,5-benzenetriol 70413-04-6
Spasfon 79173-14-1
Vidalol B 137182-40-2
Vidalol A 137182-39-9

Wikipedia Linking: http://en.wikipedia.org/wiki/Phloroglucinol

Phloroglucinol compounds of therapeutic interest: global patent and technology status - Phloroglucinol compounds, both synthetic as well as natural, have shown a vast array of biological activities. There are a wide range of applications of phloroglucinol compounds in pharmaceuticals, cosmetics, textiles, paints and dyeing industries. Although many of the phloroglucinols have shown promising results in various biological assays, very few have reached clinics. Objective: To compile the patented information on various therapeutically active phloroglucinol molecules, so that technologies used in isolation and activity assessment of these compounds could be unearthed and the compiled information be utilized for further development of these molecules. Methods: The European Patent Office database (official website: espacenet.com) was searched with a keyword ˇ°phloroglucinolˇ±. In addition, patents were searched using names of compounds listed in our previous review. Conclusions: This class holds potential for development of molecules in various therapeutic areas. There exist a number of patents on preparations that have phloroglucinol compounds as active ingredient(s). Many such preparations have been tested in vitro and/or in vivo for their efficacy and proven to be active and non-toxic. Commercialization of existing technology on phloroglucinol molecules can yield fruitful results......... (http://www.anu.edu.au/)
SALES SPECIFICATION

APPEARANCE

 white to off-white powder

CONTENT

99.0%

MOISTURE

0.5% max
TRANSPORTATION
PACKING

 

HAZARD CLASS Not regulated
UN NO.  
PRICE INFORMATION